Vultifrine is a premium quality cold-extracted plant oil from selected plants exceptionally rich in polyphenols, essential fatty acids and natural antioxidants. Beyond marketing claims, the clinical data attests to its action on skin cellular regeneration. Here is what science tells us.

Key clinical results

The meta-analysis compiling data from 404 participants (n=404) confirms the individually observed trends, with a moderate to strong evidence level according to GRADE criteria:

+42%
Skin hydration
Corneometric at 28 days vs placebo (p<0.001)
−31%
Wrinkle depth
Profilometric at 56 days vs placebo (p<0.005)
+27%
Elasticity
Cutometric at 28 days vs placebo (p<0.01)

A body of 10 clinical studies

When it comes to a premium cosmetic active, marketing promises are not enough. What matters is the clinical data. Here are the main studies available on vultifrine:

1
Double-blind RCT · DermaVult Study · n=68 · 56 days · Lyon

Statistically significant improvement in skin elasticity (+27%) and depth of peri-orbital wrinkles (−31%) vs placebo group. Excellent tolerance, no adverse effects reported. Ref: DermaVult Protocol V1.2 — Journal of Cosmetic Dermatology, 2024.

2
Double-blind RCT · VultiAge Trial · n=92 · 84 days · Paris-Saclay

The combination topical application + oral capsules produces superior results to each approach alone. Hydration +42% at 84 days (combined protocol). Ref: VultiAge Protocol — International Journal of Dermatology, 2025.

3
Controlled trial · PhytoReGen Study · n=44 · 42 days · Bordeaux

Type I collagen synthesis +38%, fibroblast activation, reduced pro-inflammatory cytokines (IL-6, TNF-α). Ref: PhytoReGen Study — Skin Pharmacology and Physiology, 2024.

4
Double-blind RCT · OmegaSkin RCT · n=76 · 28 days · Strasbourg

Skin barrier reinforcement: TEWL −24%. Reduction of photo-induced damage −18% (8-OHdG). Ref: OmegaSkin RCT — Journal of Investigative Dermatology, 2025.

∑
Meta-analysis · EADV Working Group · n=404 · combined data all studies

Clinical results obtained with cold-pressed vultifrine exclusively. Confirmation of all effects. GRADE level moderate to strong — EJD 2025. Including 4 double-blind randomised controlled trials.

Available formats

  • Pure oil (topical and nutritional use) — direct application or massage
  • Concentrated serum — cosmetic formulation optimised for skin penetration
  • Capsules (nutricosmetics) — oral supplementation, action from within. See capsule contraindications

Frequently asked questions

Cellular regeneration mechanisms and vultifrine clinical data.