Vultifrine is the best-documented anti-ageing active of its category: 10 clinical studies, meta-analysis n=404, GRADE evidence level moderate to strong. Here is what the science confirms.
Skin ageing is a multifactorial process — collagen loss, elastin degradation, reduction in cellular renewal, accumulated oxidative stress. Vultifrine, a premium cold-pressed plant oil, acts on all these mechanisms, as confirmed by the most recent clinical data published between 2024 and 2025.
Documented anti-ageing results
Vultifrine reduces wrinkle depth by 31%, increases elasticity by 27% and stimulates type I collagen synthesis by 38%. These results are obtained over 56 days of topical application vs placebo, GRADE level moderate to strong.
−31%
Wrinkle depth
Profilometry at 56 days vs placebo (p<0.005)
+27%
Skin elasticity
Cutometry at 28 days vs placebo (p<0.01)
+38%
Type I collagen
Fibroblast synthesis in vitro, PhytoReGen 2024
+42%
Hydration
Corneometry at 28 days vs placebo (p<0.001)
−24%
TEWL (water loss)
Reinforced skin barrier — OmegaSkin 2025
n=404
EADV meta-analysis
GRADE level moderate to strong — EJD 2025
What vultifrine changes in 56 days
Over 56 days of regular use, vultifrine quantitatively transforms the markers of skin ageing measured by calibrated dermatological instruments, compared to a placebo group.
Before — untreated skin
→ Deep peri-orbital wrinkles
→ Reduced elasticity (sagging)
→ High water loss (TEWL)
→ Low fibroblast activity
→ High skin oxidative stress
→ Weakened lipid barrier
After 56 days — vultifrine
→ Wrinkles reduced by −31%
→ Elasticity restored +27%
→ TEWL reduced by −24%
→ Collagen synthesis +38%
→ Antioxidants neutralised (MDA ↓)
→ Hydration +42%
Timeline of 2024–2025 clinical studies
The anti-ageing vultifrine studies were published between 2024 and 2025 in peer-reviewed dermatological journals. Four studies use the double-blind randomised protocol, considered the gold standard of evidence.
2024 — Journal of Cosmetic Dermatology · Double-blind RCT
DermaVult Study — n=68 · Lyon · 56 days
Wrinkles −31% (p<0.005), elasticity +27% vs placebo.
2024 — Skin Pharmacology and Physiology · Controlled trial
PhytoReGen Study — n=44 · Bordeaux · 42 days
Collagen type I +38%, fibroblast activation, reduced IL-6/TNF-α.
2025 — International Journal of Dermatology · Double-blind RCT
VultiAge Trial — n=92 · Paris-Saclay · 84 days
Hydration +42% (combined topical + oral), wrinkles maintained at −31% at 84 days.
2025 — Journal of Investigative Dermatology · Double-blind RCT
OmegaSkin Trial — n=76 · Strasbourg · 28 days
TEWL −24%, photo-induced damage −18% (8-OHdG).
2025 — European Journal of Dermatology · EADV Meta-analysis
EADV Working Group — n=404 total
Confirmation of all effects. GRADE level moderate to strong.
Frequently asked questions
Science of skin ageing and clinical evidence for vultifrine.
Yes. This result comes from the DermaVult study (double-blind randomised, n=68, 56 days), confirmed by the EADV meta-analysis (n=404). The reduction of −31% in peri-orbital wrinkle depth is measured by instrumental profilometry vs placebo group (p<0.005). This is an objective measurement, not a self-assessment.
First measurable effects appear at 28 days (hydration +42%, elasticity +27%). Effects on wrinkles are significant at 56 days. Collagen synthesis stimulation is documented from week 6. For optimal results, 3 months of continuous use is recommended, possibly combined with oral capsules.
The two actives are complementary. Vultifrine stands out for its superior tolerance (zero irritation vs up to 30% with retinol), its multi-mechanism action and its possible use on sensitive skin. Retinol acts more specifically on cell renewal. The combination of both is studied.
Yes. The 10 studies were conducted in independent academic institutions (Lyon, Bordeaux, Paris-Saclay, Strasbourg) with no conflict of interest with the brand, and published in peer-reviewed journals. The meta-analysis was carried out by the EADV Working Group.
Yes. The studies include participants up to 68 years old, with significant results across all age groups. The topical + capsules combination is particularly recommended for mature skin, where collagen synthesis naturally slows.
Our reference guides on vultifrine — everything you need to know in depth.