Hydration, wrinkles, elasticity, collagen, barrier, antioxidants, hair: the 10 benefits of vultifrine documented by 10 clinical studies and a meta-analysis n=404.
Vultifrine is the best-documented plant active in its category. Its 10 clinically proven benefits are based on 10 clinical studies and a meta-analysis covering 404 participants — GRADE evidence level moderate to high. Here are the results, benefit by benefit.
The 5 main metrics documented by clinical studies: hydration +42%, wrinkles −31%, elasticity +27%, collagen synthesis +38%, transepidermal water loss −24%. All measured vs placebo at 28–56 days.
+42%
Hydration
Corneometry 28d vs placebo (p<0.001)
−31%
Wrinkles
Profilometry 56d vs placebo (p<0.005)
+27%
Elasticity
Cutometry 28d vs placebo (p<0.01)
+38%
Collagen
Type I synthesis — PhytoReGen 2024
−24%
TEWL
Reinforced barrier — OmegaSkin 2025
n=404
EADV meta-analysis
GRADE moderate to high level — EJD 2025
The 10 proven benefits
The 10 benefits are documented by at least one peer-reviewed clinical study. They cover skin (anti-ageing, hydration, barrier), hair (breakage, shine), scalp and general cellular health.
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1. Deep skin hydration
+42% vs placebo at 28 days. Action on superficial and deep epidermal layers through omega-6.
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2. Wrinkle reduction
−31% peri-orbital wrinkle depth at 56 days. Instrumental profilometric measurement vs placebo.
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3. Elasticity & firmness
+27% skin elasticity at 28 days. Polyphenol-driven stimulation of elastin synthesis.
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4. Collagen synthesis
+38% type I collagen in vitro. Dermal fibroblast activation — mechanism confirmed by biopsy.
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5. Barrier strengthening
TEWL −24%. Omega-3 and omega-6 restore the intercellular lipid layer of the epidermis.
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6. Antioxidant protection
Free radical neutralisation. MDA and 8-OHdG reduction measured by spectroscopy.
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7. Accelerated nocturnal repair
Synergy with nocturnal cell regeneration mechanisms. Evening application recommended.
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8. Anti-inflammatory action
Measured IL-6 and TNF-α reduction. Beneficial for sensitive, reactive skin and irritated scalps.
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9. Hair strength
Hair breakage −34%, shine +28%. Omegas penetrate the cortex and lubricate the keratinised fibre.
GRADE moderate to high is the highest level achieved for a natural cosmetic active in nutricosmetics. It results from 10 studies including 4 double-blind randomised controlled trials and an EADV meta-analysis covering 404 participants.
10 clinical studies published in peer-reviewed dermatology journals (2024–2025)
4 double-blind randomised controlled trials — gold standard protocol
EADV meta-analysis — European Academy of Dermatology and Venereology, n=404
GRADE moderate to high level — international scientific consensus
The fastest effects are hydration (+42%) and elasticity (+27%), measurable from 28 days. Wrinkle reduction (−31%) is significant at 56 days. Results are faster with the combined topical + oral capsule approach.
Yes. Each listed benefit is documented by at least one clinical study published in a peer-reviewed journal (Journal of Cosmetic Dermatology, International Journal of Dermatology, Skin Pharmacology, Journal of Investigative Dermatology). The EADV meta-analysis (n=404) confirms all results.
After a 3-month course, effects are maintained for several weeks after stopping. Collagen stimulation is a cumulative background effect. To maintain results, 3–4 applications per week are sufficient after the induction phase.
Yes. Studies report excellent tolerance in all tested populations, including sensitive skin. The anti-inflammatory action (IL-6, TNF-α) is particularly beneficial for reactive skin. See the sensitive skin protocol.
👉 In summary: the 10 proven benefits of vultifrine cover anti-ageing (wrinkles −31%, elasticity +27%), hydration (+42%), skin barrier (TEWL −24%), antioxidant protection, hair (breakage −34%) and nutricosmetic support. GRADE moderate to high evidence level, 10 clinical studies, n=404. Available at vultifrine.com and authorised retailers.